Ion-Exchange Resins as Controlled Drug Delivery Carriers

Ion-exchange resins as drug delivery carriers.

There are many reports in the literature referring to the utilization of drug bound to ion-exchange resin (drug-resinate), especially in the drug delivery area. Ion-exchange resin complexes, which can be prepared from both acidic and basic drugs, have been widely studied and marketed. Salts of cationic and anionic exchange resins are insoluble complexes in which drug release results from exchan...

Ion Exchange Resins as Excipients for Drug Delivery: Issues for Reproducible Drug Loading

A method for repeatable loading of propranolol hydrochloride as a model drug onto the ion exchanger Amberlite TM IRP69 was developed and different parameters for the loading process were evaluated due to their impact of the extent of loading. It was found that the extent of loading in equilibrium is widely independent of the experimental method used. However, a magnetic stirrer comminutes the i...

Controlled Transdermal Drug Delivery by Iontophoresis and Ion-exchange Fiber

Kankkunen, T., 2002. Controlled transdermal drug delivery by iontophoresis and ionexchange fiber. Dissertationes Biocentri Viikki Universitatis Helsingiensis 17/2002, pp. 57 ISBN 952-10-0313-8 (print) ISBN 952-10-0314-6 (pdf) ISSN 1239-9469 A common aim in the development of new transdermal devices is the controlled delivery of drugs, so that the rate of drug input into the blood stream is pred...

[Ion exchange resins].

Ion exchange resins have been used to help formulate pharmaceuticals since the late 1950's. During that time they have proved to be safe and effective excipients and are now used in many commercial formulations throughout the world. In this article we will look at some of the common problems faced by formulators and how using ion exchange resins may be able to solve them. Ion exchange resins ar...

Multiparticulate Carriers for Controlled Oral Drug Delivery